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"Nephrology Provider Prognostic Perceptions and Care Delivered to Older Adults with Advanced Kidney Disease" in CJASN

September 20th 2017

"Nephrology Provider Prognostic Perceptions and Care Delivered to Older Adults with Advanced Kidney Disease"  published in CJASN with several VCKD members as authors.

Huzaifah Salat, Andrei Javier, Edward D. Siew, Rocio Figueroa, Loren Lipworth, Edmond Kabagambe, Aihua Bian‖, Thomas G. Stewart‖, Maie H. El-Sourady,Mohana Karlekar,  Cesar Y. Cardona, T. Alp Ikizler, Khaled Abdel-Kader

Correspondence:Dr. Khaled Abdel-Kader, Division of Nephrology, Vanderbilt University, 1161 21st Avenue South, MCN S-3223, Nashville, TN 37232.Email:

H.S. and A.J. contributed equally to this work.


Background and objectives Prognostic uncertainty is one barrier that impedes providers in engaging patients with CKD in shared decision making and advance care planning. The surprise question has been shown to identify patients at increased risk of dying.

Design, setting, participants, & measurements In our prospective observational study, 488 patients ≥60 years of age with CKD stage 4 or 5 were enrolled. Binary surprise question (i.e., “Would you be surprised if this patient died in the next 12 months?”) responses were recorded, and dialysis planning preferences, presence of advance care planning documentation, and care preceding death were abstracted.


The median patient age was 71 (65–77) years old. Providers responded no and yes to the surprise question for 171 (35%) and 317 (65%) patients, respectively. Median follow-up was 1.9 (1.5–2.1) years, during which 18% of patients died (33% of surprise question no, 10% of surprise question yes; P<0.001). In patients with a known RRT preference (58%), 13% of surprise question no participants had a preference for conservative management (versus 2% of yes counterparts; P<0.001). A medical order (i.e., physician order for life-sustaining treatment) was documented in 13% of surprise question no patients versus 5% of yes patients (P=0.004). Among surprise question no decedents, 41% died at home or hospice, 38% used hospice services, and 54% were hospitalized in the month before death. In surprise question yes decedents, 39% died at home or hospice (P=0.90 versus no), 26% used hospice services (P=0.50 versus no), and 67% were hospitalized in the month before death (P=0.40 versus surprise question no).


Nephrologists’ prognostic perceptions were associated with modest changes in care, highlighting a critical gap in conservative management discussions, advance care planning, and end of life care among older adults with CKD stages 4 and 5 and high-risk clinical characteristics.

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