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Agnes B Fogo M.D.

Department: Vanderbilt Center for Kidney Disease

Biography

Research efforts primarily concern renal pathology and involve: 1) basic research in mechanisms and pathophysiology of progression of chronic renal disease; including regression/remodeling of sclerosis; 2) basic research in mechanisms and pathophysiology of the renin angiotensin system; and 3) applied renal pathology with emphasis on prognostic features in minimal change disease/focal glomerulosclerosis.

Chronic rat animal models and knock-out mice are used to investigate the interactions of fibrotic and thrombotic mechanisms. Our work focuses on contributions of the renin angiotensin system to structural damage, and its interactions with other growth factors, and with mechanisms of thrombosis (i.e. plasmin/plasminogen activator system). Approaches include classical pathology, molecular biology and functional assessments.

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