
Billy G. Hudson Ph.D.
Department: Medicine
Biography
Dr. Billy G. Hudson, Ph.D., is the Elliot V. Newman Professor of Medicine, Biochemistry and Pathology, Microbiology and Immunology, and Director of the Center for Matrix Biology at Vanderbilt University. His research has focused on ancient collagen proteins that compose basement membranes, a specialized form of extracellular matrix that underlies epithelia cells. The matrix is essential for the development and maintenance of tissue architecture and function in all multi-cellular organisms from sponge to human. His research group discovered two collagen proteins, and named them alpha-3 and alpha-4 chains of collagen IV, and described how they, together with an alpha-5 chain, assemble into a complex α3α4α5 network that functions as a key component of the kidney filtration barrier. The network is directly involved in the pathogenic mechanisms underlying several diseases that cause kidney failure in millions of people: autoimmune Goodpasture syndrome; hereditary Alport syndrome; thin basement membrane nephropathy, Alport post-transplant nephritis, and diabetic renal disease. His work has defined the three-dimensional structure and antibody binding sites of the autoantigen of Goodpasture syndrome, and discovered a new sulfur-nitrogen chemical bond (=S=N-), named sulifilimine bond, that fastens the autoantigen together, uncovering clues to the pathogenesis of a prototype autoimmune disease, Science (2009).
Recently the Hudson team discovered the enzyme, named peroxidasin that forms the sulifilimine chemical bond, Nature Chemical Biology (2012), and the evolutionary origin of the sulfilimine chemical bond and peroxidasin, Proceedings of the National Academy of Sciences (2014). Just recently, they discovered that the trace element bromine is required for bond formation and that bromine is an essential trace element for tissue genesis throughout the animal kingdom, Cell (2014). These discoveries profile collagen IV scaffolds (suliflimine-crosslinked) as a primordial innovation that is essential for tissue evolution.
He is a co-founder of NephroGenex, a biotech company that is developing Pyridorin, a drug-candidate which was discovered in his laboratory for the prevention of diabetic kidney disease. A phase III clinical trial will begin 2014. He is also co-founder, along with wife, Dr. Julie Hudson, of “Aspirnaut”, an educational initiative that encourages students, kindergarten thru undergraduate, to pursue studies and careers in science, technology, engineering and mathematics.
Billy received his Ph.D. from the University of Iowa in 1966 and performed his postdoctoral training at Harvard University and the U.S. Army Research Institute of Environmental Medicine. He is the coauthor of over 200 scientific publications and 30 patents.
Featured Publications
1. Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.
Ooi JD, Petersen J, Tan YH, Huynh M, Willett ZJ, Ramarathinam SH, Eggenhuizen PJ, Loh KL, Watson KA, Gan PY, Alikhan MA, Dudek NL, Handel A, Hudson BG, Fugger L, Power DA, Holt SG, Coates PT, Gregersen JW, Purcell AW, Holdsworth SR, La Gruta NL, Reid HH, Rossjohn J, Kitching AR (2017) Nature 545(7653): 243-247
Citation ⋅ 28467828 (PubMed)2. Collagen IV and basement membrane at the evolutionary dawn of metazoan tissues.
Fidler AL, Darris CE, Chetyrkin SV, Pedchenko VK, Boudko SP, Brown KL, Gray Jerome W, Hudson JK, Rokas A, Hudson BG (2017) Elife 6():
Citation ⋅ 28418331 (PubMed) PMC5395295 (PubMed Central)3. The susceptible HLA class II alleles and their presenting epitope(s) in Goodpasture's disease.
Xie LJ, Cui Z, Chen FJ, Pei ZY, Hu SY, Gu QH, Jia XY, Zhu L, Zhou XJ, Zhang H, Liao YH, Lai LH, Hudson BG, Zhao MH (2017) Immunology 151(4): 395-404
Citation ⋅ 28342268 (PubMed) PMC5506429 (PubMed Central)Publications
1. Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells.
Ooi JD, Petersen J, Tan YH, Huynh M, Willett ZJ, Ramarathinam SH, Eggenhuizen PJ, Loh KL, Watson KA, Gan PY, Alikhan MA, Dudek NL, Handel A, Hudson BG, Fugger L, Power DA, Holt SG, Coates PT, Gregersen JW, Purcell AW, Holdsworth SR, La Gruta NL, Reid HH, Rossjohn J, Kitching AR (2017) Nature 545(7653): 243-247
Citation ⋅ 28467828 (PubMed)2. Collagen IV and basement membrane at the evolutionary dawn of metazoan tissues.
Fidler AL, Darris CE, Chetyrkin SV, Pedchenko VK, Boudko SP, Brown KL, Gray Jerome W, Hudson JK, Rokas A, Hudson BG (2017) Elife 6():
Citation ⋅ 28418331 (PubMed) PMC5395295 (PubMed Central)3. The susceptible HLA class II alleles and their presenting epitope(s) in Goodpasture's disease.
Xie LJ, Cui Z, Chen FJ, Pei ZY, Hu SY, Gu QH, Jia XY, Zhu L, Zhou XJ, Zhang H, Liao YH, Lai LH, Hudson BG, Zhao MH (2017) Immunology 151(4): 395-404
Citation ⋅ 28342268 (PubMed) PMC5506429 (PubMed Central)4. Implications of the differing roles of the β1 and β3 transmembrane and cytoplasmic domains for integrin function.
Lu Z, Mathew S, Chen J, Hadziselimovic A, Palamuttam R, Hudson BG, Fässler R, Pozzi A, Sanders CR, Zent R (2016) Elife 5():
Citation ⋅ 27929375 (PubMed) PMC5207772 (PubMed Central)5. Basement membrane ultrastructure and component localization data from uterine tissues during early mouse pregnancy.
Jones-Paris CR, Paria S, Berg T, Saus J, Bhave G, Paria BC, Hudson BG (2016) Data Brief 9(): 931-939
Citation ⋅ 27896299 (PubMed) PMC5118616 (PubMed Central)6. Lysyl Oxidase-like-2 Cross-links Collagen IV of Glomerular Basement Membrane.
Añazco C, López-Jiménez AJ, Rafi M, Vega-Montoto L, Zhang MZ, Hudson BG, Vanacore RM (2016) J Biol Chem 291(50): 25999-26012
Citation ⋅ 27770022 (PubMed) PMC5207071 (PubMed Central)7. Embryo implantation triggers dynamic spatiotemporal expression of the basement membrane toolkit during uterine reprogramming.
Jones-Paris CR, Paria S, Berg T, Saus J, Bhave G, Paria BC, Hudson BG (2017) Matrix Biol 57-58(): 347-365
Citation ⋅ 27619726 (PubMed) PMC5328942 (PubMed Central)8. Extracellular chloride signals collagen IV network assembly during basement membrane formation.
Cummings CF, Pedchenko V, Brown KL, Colon S, Rafi M, Jones-Paris C, Pokydeshava E, Liu M, Pastor-Pareja JC, Stothers C, Ero-Tolliver IA, McCall AS, Vanacore R, Bhave G, Santoro S, Blackwell TS, Zent R, Pozzi A, Hudson BG (2016) J Cell Biol 213(4): 479-94
Citation ⋅ 27216258 (PubMed) PMC4878091 (PubMed Central)9. Pyridoxamine reduces postinjury fibrosis and improves functional recovery after acute kidney injury.
Skrypnyk NI, Voziyan P, Yang H, de Caestecker CR, Theberge MC, Drouin M, Hudson B, Harris RC, de Caestecker MP (2016) Am J Physiol Renal Physiol 311(2): F268-77
Citation ⋅ 27194713 (PubMed) PMC5008672 (PubMed Central)10. Antibodies to α5 chain of collagen IV are pathogenic in Goodpasture's disease.
Cui Z, Zhao MH, Jia XY, Wang M, Hu SY, Wang SX, Yu F, Brown KL, Hudson BG, Pedchenko V (2016) J Autoimmun 70(): 1-11
Citation ⋅ 27117167 (PubMed) PMC5600521 (PubMed Central)11. Comprehensive Characterization of Glycosylation and Hydroxylation of Basement Membrane Collagen IV by High-Resolution Mass Spectrometry.
Basak T, Vega-Montoto L, Zimmerman LJ, Tabb DL, Hudson BG, Vanacore RM (2016) J Proteome Res 15(1): 245-58
Citation ⋅ 26593852 (PubMed) PMC4771517 (PubMed Central)12. Decellularization of intact tissue enables MALDI imaging mass spectrometry analysis of the extracellular matrix.
Gessel M, Spraggins JM, Voziyan P, Hudson BG, Caprioli RM (2015) J Mass Spectrom 50(11): 1288-93
Citation ⋅ 26505774 (PubMed) PMC5320948 (PubMed Central)13. The Ancient Immunoglobulin Domains of Peroxidasin Are Required to Form Sulfilimine Cross-links in Collagen IV.
Ero-Tolliver IA, Hudson BG, Bhave G (2015) J Biol Chem 290(35): 21741-8
Citation ⋅ 26178375 (PubMed) PMC4571896 (PubMed Central)14. Pyridoxamine protects proteins from damage by hypohalous acids in vitro and in vivo.
Madu H, Avance J, Chetyrkin S, Darris C, Rose KL, Sanchez OA, Hudson B, Voziyan P (2015) Free Radic Biol Med 89(): 83-90
Citation ⋅ 26159508 (PubMed) PMC4684779 (PubMed Central)15. Hypohalous acids contribute to renal extracellular matrix damage in experimental diabetes.
Brown KL, Darris C, Rose KL, Sanchez OA, Madu H, Avance J, Brooks N, Zhang MZ, Fogo A, Harris R, Hudson BG, Voziyan P (2015) Diabetes 64(6): 2242-53
Citation ⋅ 25605804 (PubMed) PMC4439565 (PubMed Central)16. Supramolecular organization of the α121-α565 collagen IV network.
Robertson WE, Rose KL, Hudson BG, Vanacore RM (2014) J Biol Chem 289(37): 25601-10
Citation ⋅ 25006246 (PubMed) PMC4162165 (PubMed Central)17. Bromine is an essential trace element for assembly of collagen IV scaffolds in tissue development and architecture.
McCall AS, Cummings CF, Bhave G, Vanacore R, Page-McCaw A, Hudson BG (2014) Cell 157(6): 1380-92
Citation ⋅ 24906154 (PubMed) PMC4144415 (PubMed Central)18. Diabetic nephropathy induces alterations in the glomerular and tubule lipid profiles.
Grove KJ, Voziyan PA, Spraggins JM, Wang S, Paueksakon P, Harris RC, Hudson BG, Caprioli RM (2014) J Lipid Res 55(7): 1375-85
Citation ⋅ 24864273 (PubMed) PMC4076088 (PubMed Central)19. Propagating the nephrology research workforce: a Kidney Research National Dialogue training commentary.
Kohan DE, Parker MG, Furth SL, Hudson BG, Warburton KM, Rys-Sikora KE, Rankin TL, Kidney Research National Dialogue (2014) Clin J Am Soc Nephrol 9(6): 1144-7
Citation ⋅ 24626430 (PubMed) PMC4046718 (PubMed Central)20. Lens capsule as a model to study type IV collagen.
Cummings CF, Hudson BG (2014) Connect Tissue Res 55(1): 8-12
Citation ⋅ 24437599 (PubMed) PMC4138812 (PubMed Central)21. A unique covalent bond in basement membrane is a primordial innovation for tissue evolution.
Fidler AL, Vanacore RM, Chetyrkin SV, Pedchenko VK, Bhave G, Yin VP, Stothers CL, Rose KL, McDonald WH, Clark TA, Borza DB, Steele RE, Ivy MT, Aspirnauts, Hudson JK, Hudson BG (2014) Proc Natl Acad Sci U S A 111(1): 331-6
Citation ⋅ 24344311 (PubMed) PMC3890831 (PubMed Central)22. Quaternary epitopes of α345(IV) collagen initiate Alport post-transplant anti-GBM nephritis.
Olaru F, Luo W, Wang XP, Ge L, Hertz JM, Kashtan CE, Sado Y, Segal Y, Hudson BG, Borza DB (2013) J Am Soc Nephrol 24(6): 889-95
Citation ⋅ 23620401 (PubMed) PMC3665397 (PubMed Central)23. Site-specific AGE modifications in the extracellular matrix: a role for glyoxal in protein damage in diabetes.
Voziyan P, Brown KL, Chetyrkin S, Hudson B (2014) Clin Chem Lab Med 52(1): 39-45
Citation ⋅ 23492568 (PubMed) PMC4104777 (PubMed Central)24. The HLA-DRB1*15:01-restricted Goodpasture's T cell epitope induces GN.
Ooi JD, Chang J, O'Sullivan KM, Pedchenko V, Hudson BG, Vandenbark AA, Fugger L, Holdsworth SR, Kitching AR (2013) J Am Soc Nephrol 24(3): 419-31
Citation ⋅ 23411782 (PubMed) PMC3582203 (PubMed Central)25. Upregulated expression of integrin α1 in mesangial cells and integrin α3 and vimentin in podocytes of Col4a3-null (Alport) mice.
Steenhard BM, Vanacore R, Friedman D, Zelenchuk A, Stroganova L, Isom K, St John PL, Hudson BG, Abrahamson DR (2012) PLoS One 7(12): e50745
Citation ⋅ 23236390 (PubMed) PMC3517557 (PubMed Central)26. Enhancing integrin α1 inserted (I) domain affinity to ligand potentiates integrin α1β1-mediated down-regulation of collagen synthesis.
Shi M, Pedchenko V, Greer BH, Van Horn WD, Santoro SA, Sanders CR, Hudson BG, Eichman BF, Zent R, Pozzi A (2012) J Biol Chem 287(42): 35139-52
Citation ⋅ 22888006 (PubMed) PMC3471707 (PubMed Central)27. Peroxidasin forms sulfilimine chemical bonds using hypohalous acids in tissue genesis.
Bhave G, Cummings CF, Vanacore RM, Kumagai-Cresse C, Ero-Tolliver IA, Rafi M, Kang JS, Pedchenko V, Fessler LI, Fessler JH, Hudson BG (2012) Nat Chem Biol 8(9): 784-90
Citation ⋅ 22842973 (PubMed) PMC4128002 (PubMed Central)28. Inhibition of integrin α2β1 ameliorates glomerular injury.
Borza CM, Su Y, Chen X, Yu L, Mont S, Chetyrkin S, Voziyan P, Hudson BG, Billings PC, Jo H, Bennett JS, Degrado WF, Eckes B, Zent R, Pozzi A (2012) J Am Soc Nephrol 23(6): 1027-38
Citation ⋅ 22440900 (PubMed) PMC3358756 (PubMed Central)29. Goodpasture antigen-binding protein (GPBP) directs myofibril formation: identification of intracellular downstream effector 130-kDa GPBP-interacting protein (GIP130).
Revert-Ros F, López-Pascual E, Granero-Moltó F, Macías J, Breyer R, Zent R, Hudson BG, Saadeddin A, Revert F, Blasco R, Navarro C, Burks D, Saus J (2011) J Biol Chem 286(40): 35030-43
Citation ⋅ 21832087 (PubMed) PMC3186396 (PubMed Central)30. Pyridoxamine protects protein backbone from oxidative fragmentation.
Chetyrkin S, Mathis M, Hayes McDonald W, Shackelford X, Hudson B, Voziyan P (2011) Biochem Biophys Res Commun 411(3): 574-9
Citation ⋅ 21763683 (PubMed) PMC3153140 (PubMed Central)31. Glucose autoxidation induces functional damage to proteins via modification of critical arginine residues.
Chetyrkin S, Mathis M, Pedchenko V, Sanchez OA, McDonald WH, Hachey DL, Madu H, Stec D, Hudson B, Voziyan P (2011) Biochemistry 50(27): 6102-12
Citation ⋅ 21661747 (PubMed) PMC3140462 (PubMed Central)32. Sulphilimine cross-links in Goodpasture's disease.
Vanacore R, Pedchenko V, Bhave G, Hudson BG (2011) Clin Exp Immunol 164 Suppl 1(): 4-6
Citation ⋅ 21447121 (PubMed) PMC3095855 (PubMed Central)33. Goodpasture's disease: molecular architecture of the autoantigen provides clues to etiology and pathogenesis.
Pedchenko V, Vanacore R, Hudson B (2011) Curr Opin Nephrol Hypertens 20(3): 290-6
Citation ⋅ 21378566 (PubMed) PMC3159420 (PubMed Central)34. Mapping structural landmarks, ligand binding sites, and missense mutations to the collagen IV heterotrimers predicts major functional domains, novel interactions, and variation in phenotypes in inherited diseases affecting basement membranes.
Parkin JD, San Antonio JD, Pedchenko V, Hudson B, Jensen ST, Savige J (2011) Hum Mutat 32(2): 127-43
Citation ⋅ 21280145 (PubMed) PMC4800984 (PubMed Central)35. Molecular architecture of the Goodpasture autoantigen in anti-GBM nephritis.
Pedchenko V, Bondar O, Fogo AB, Vanacore R, Voziyan P, Kitching AR, Wieslander J, Kashtan C, Borza DB, Neilson EG, Wilson CB, Hudson BG (2010) N Engl J Med 363(4): 343-54
Citation ⋅ 20660402 (PubMed) PMC4144421 (PubMed Central)36. MT2-MMP-dependent release of collagen IV NC1 domains regulates submandibular gland branching morphogenesis.
Rebustini IT, Myers C, Lassiter KS, Surmak A, Szabova L, Holmbeck K, Pedchenko V, Hudson BG, Hoffman MP (2009) Dev Cell 17(4): 482-93
Citation ⋅ 19853562 (PubMed) PMC2768621 (PubMed Central)37. A sulfilimine bond identified in collagen IV.
Vanacore R, Ham AJ, Voehler M, Sanders CR, Conrads TP, Veenstra TD, Sharpless KB, Dawson PE, Hudson BG (2009) Science 325(5945): 1230-4
Citation ⋅ 19729652 (PubMed) PMC2876822 (PubMed Central)38. Modification of collagen IV by glucose or methylglyoxal alters distinct mesangial cell functions.
Pozzi A, Zent R, Chetyrkin S, Borza C, Bulus N, Chuang P, Chen D, Hudson B, Voziyan P (2009) J Am Soc Nephrol 20(10): 2119-25
Citation ⋅ 19608705 (PubMed) PMC2754111 (PubMed Central)39. Pyridoxamine protects intestinal epithelium from ionizing radiation-induced apoptosis.
Thotala D, Chetyrkin S, Hudson B, Hallahan D, Voziyan P, Yazlovitskaya E (2009) Free Radic Biol Med 47(6): 779-85
Citation ⋅ 19540915 (PubMed) PMC2739572 (PubMed Central)40. Cellular origins of type IV collagen networks in developing glomeruli.
Abrahamson DR, Hudson BG, Stroganova L, Borza DB, St John PL (2009) J Am Soc Nephrol 20(7): 1471-9
Citation ⋅ 19423686 (PubMed) PMC2709682 (PubMed Central)41. Regulation of matrix synthesis, remodeling and accumulation in glomerulosclerosis.
Pozzi A, Voziyan PA, Hudson BG, Zent R (2009) Curr Pharm Des 15(12): 1318-33
Citation ⋅ 19355971 (PubMed)42. Selective binding of integrins from different renal cell types to the NC1 domain of alpha3 and alpha1 chains of type IV collagen.
Aggeli AS, Kitsiou PV, Tzinia AK, Boutaud A, Hudson BG, Tsilibary EC (2009) J Nephrol 22(1): 130-6
Citation ⋅ 19229828 (PubMed)43. Stem cell therapy for Alport syndrome: the hope beyond the hype.
Gross O, Borza DB, Anders HJ, Licht C, Weber M, Segerer S, Torra R, Gubler MC, Heidet L, Harvey S, Cosgrove D, Lees G, Kashtan C, Gregory M, Savige J, Ding J, Thorner P, Abrahamson DR, Antignac C, Tryggvason K, Hudson B, Miner JH (2009) Nephrol Dial Transplant 24(3): 731-4
Citation ⋅ 19110486 (PubMed) PMC3888105 (PubMed Central)44. Identification of noncollagenous sites encoding specific interactions and quaternary assembly of alpha 3 alpha 4 alpha 5(IV) collagen: implications for Alport gene therapy.
Kang JS, Colon S, Hellmark T, Sado Y, Hudson BG, Borza DB (2008) J Biol Chem 283(50): 35070-7
Citation ⋅ 18930919 (PubMed) PMC2596392 (PubMed Central)45. Cross-talk between integrins alpha1beta1 and alpha2beta1 in renal epithelial cells.
Abair TD, Sundaramoorthy M, Chen D, Heino J, Ivaska J, Hudson BG, Sanders CR, Pozzi A, Zent R (2008) Exp Cell Res 314(19): 3593-604
Citation ⋅ 18809396 (PubMed) PMC2729514 (PubMed Central)46. A role for collagen IV cross-links in conferring immune privilege to the Goodpasture autoantigen: structural basis for the crypticity of B cell epitopes.
Vanacore RM, Ham AJ, Cartailler JP, Sundaramoorthy M, Todd P, Pedchenko V, Sado Y, Borza DB, Hudson BG (2008) J Biol Chem 283(33): 22737-48
Citation ⋅ 18499662 (PubMed) PMC2504875 (PubMed Central)47. Goodpasture antigen-binding protein and its spliced variant, ceramide transfer protein, have different functions in the modulation of apoptosis during zebrafish development.
Granero-Moltó F, Sarmah S, O'Rear L, Spagnoli A, Abrahamson D, Saus J, Hudson BG, Knapik EW (2008) J Biol Chem 283(29): 20495-504
Citation ⋅ 18424781 (PubMed) PMC2459293 (PubMed Central)48. Propagation of protein glycation damage involves modification of tryptophan residues via reactive oxygen species: inhibition by pyridoxamine.
Chetyrkin SV, Mathis ME, Ham AJ, Hachey DL, Hudson BG, Voziyan PA (2008) Free Radic Biol Med 44(7): 1276-85
Citation ⋅ 18374270 (PubMed)49. Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity.
Pozzi A, Jarad G, Moeckel GW, Coffa S, Zhang X, Gewin L, Eremina V, Hudson BG, Borza DB, Harris RC, Holzman LB, Phillips CL, Fassler R, Quaggin SE, Miner JH, Zent R (2008) Dev Biol 316(2): 288-301
Citation ⋅ 18328474 (PubMed) PMC2396524 (PubMed Central)50. Human podocytes adhere to the KRGDS motif of the alpha3alpha4alpha5 collagen IV network.
Borza CM, Borza DB, Pedchenko V, Saleem MA, Mathieson PW, Sado Y, Hudson HM, Pozzi A, Saus J, Abrahamson DR, Zent R, Hudson BG (2008) J Am Soc Nephrol 19(4): 677-84
Citation ⋅ 18235087 (PubMed) PMC2390958 (PubMed Central)51. Mammalian collagen IV.
Khoshnoodi J, Pedchenko V, Hudson BG (2008) Microsc Res Tech 71(5): 357-70
Citation ⋅ 18219669 (PubMed) PMC4788096 (PubMed Central)52. Pyridoxamine protects proteins from functional damage by 3-deoxyglucosone: mechanism of action of pyridoxamine.
Chetyrkin SV, Zhang W, Hudson BG, Serianni AS, Voziyan PA (2008) Biochemistry 47(3): 997-1006
Citation ⋅ 18161948 (PubMed)53. Distinct target-derived signals organize formation, maturation, and maintenance of motor nerve terminals.
Fox MA, Sanes JR, Borza DB, Eswarakumar VP, Fässler R, Hudson BG, John SW, Ninomiya Y, Pedchenko V, Pfaff SL, Rheault MN, Sado Y, Segal Y, Werle MJ, Umemori H (2007) Cell 129(1): 179-93
Citation ⋅ 17418794 (PubMed)54. Kidney development and gene expression in the HIF2alpha knockout mouse.
Steenhard BM, Freeburg PB, Isom K, Stroganova L, Borza DB, Hudson BG, St John PL, Zelenchuk A, Abrahamson DR (2007) Dev Dyn 236(4): 1115-25
Citation ⋅ 17342756 (PubMed)55. The alloantigenic sites of alpha3alpha4alpha5(IV) collagen: pathogenic X-linked alport alloantibodies target two accessible conformational epitopes in the alpha5NC1 domain.
Kang JS, Kashtan CE, Turner AN, Heidet L, Hudson BG, Borza DB (2007) J Biol Chem 282(14): 10670-7
Citation ⋅ 17293596 (PubMed)56. Identification of N-linked glycosylation sites in human nephrin using mass spectrometry.
Khoshnoodi J, Hill S, Tryggvason K, Hudson B, Friedman DB (2007) J Mass Spectrom 42(3): 370-9
Citation ⋅ 17212372 (PubMed)57. Pyridoxamine analogues scavenge lipid-derived gamma-ketoaldehydes and protect against H2O2-mediated cytotoxicity.
Davies SS, Brantley EJ, Voziyan PA, Amarnath V, Zagol-Ikapitte I, Boutaud O, Hudson BG, Oates JA, Roberts LJ (2006) Biochemistry 45(51): 15756-67
Citation ⋅ 17176098 (PubMed) PMC2597444 (PubMed Central)58. Molecular recognition in the assembly of collagens: terminal noncollagenous domains are key recognition modules in the formation of triple helical protomers.
Khoshnoodi J, Cartailler JP, Alvares K, Veis A, Hudson BG (2006) J Biol Chem 281(50): 38117-21
Citation ⋅ 17082192 (PubMed)59. A nephritogenic peptide induces intermolecular epitope spreading on collagen IV in experimental autoimmune glomerulonephritis.
Chen L, Hellmark T, Pedchenko V, Hudson BG, Pusey CD, Fox JW, Bolton WK (2006) J Am Soc Nephrol 17(11): 3076-81
Citation ⋅ 17005930 (PubMed)60. Tumor-specific expression of the RGD-alpha3(IV)NC1 domain suppresses endothelial tube formation and tumor growth in mice.
Miyoshi T, Hirohata S, Ogawa H, Doi M, Obika M, Yonezawa T, Sado Y, Kusachi S, Kyo S, Kondo S, Shiratori Y, Hudson BG, Ninomiya Y (2006) FASEB J 20(11): 1904-6
Citation ⋅ 16877525 (PubMed)61. Glomerular injury is exacerbated in diabetic integrin alpha1-null mice.
Zent R, Yan X, Su Y, Hudson BG, Borza DB, Moeckel GW, Qi Z, Sado Y, Breyer MD, Voziyan P, Pozzi A (2006) Kidney Int 70(3): 460-70
Citation ⋅ 16775606 (PubMed)62. Integrin alpha3beta1, a novel receptor for alpha3(IV) noncollagenous domain and a trans-dominant Inhibitor for integrin alphavbeta3.
Borza CM, Pozzi A, Borza DB, Pedchenko V, Hellmark T, Hudson BG, Zent R (2006) J Biol Chem 281(30): 20932-9
Citation ⋅ 16731529 (PubMed)63. Sequential expression of type IV collagen networks: testis as a model and relevance to spermatogenesis.
Harvey SJ, Perry J, Zheng K, Chen D, Sado Y, Jefferson B, Ninomiya Y, Jacobs R, Hudson BG, Thorner PS (2006) Am J Pathol 168(5): 1587-97
Citation ⋅ 16651625 (PubMed) PMC1606577 (PubMed Central)64. Conformational diversity of the Goodpasture antigen, the noncollagenous-1 domain of the alpha3 chain of collagen IV.
Calvete JJ, Revert F, Blanco M, Cervera J, Tárrega C, Sanz L, Revert-Ros F, Granero F, Pérez-Payá E, Hudson BG, Saus J (2006) Proteomics 6 Suppl 1(): S237-44
Citation ⋅ 16534749 (PubMed)65. Mechanism of chain selection in the assembly of collagen IV: a prominent role for the alpha2 chain.
Khoshnoodi J, Sigmundsson K, Cartailler JP, Bondar O, Sundaramoorthy M, Hudson BG (2006) J Biol Chem 281(9): 6058-69
Citation ⋅ 16373348 (PubMed)66. Pyridoxamine lowers oxalate excretion and kidney crystals in experimental hyperoxaluria: a potential therapy for primary hyperoxaluria.
Scheinman JI, Voziyan PA, Belmont JM, Chetyrkin SV, Kim D, Hudson BG (2005) Urol Res 33(5): 368-71
Citation ⋅ 16292584 (PubMed)67. Regulation of collagen type IV genes is organ-specific: evidence from a canine model of Alport syndrome.
Zheng K, Perry J, Harvey SJ, Sado Y, Ninomiya Y, Jefferson B, Jacobs R, Hudson BG, Thorner PS (2005) Kidney Int 68(5): 2121-30
Citation ⋅ 16221211 (PubMed)68. Mechanism of perturbation of integrin-mediated cell-matrix interactions by reactive carbonyl compounds and its implication for pathogenesis of diabetic nephropathy.
Pedchenko VK, Chetyrkin SV, Chuang P, Ham AJ, Saleem MA, Mathieson PW, Hudson BG, Voziyan PA (2005) Diabetes 54(10): 2952-60
Citation ⋅ 16186398 (PubMed)69. Pyridoxamine: the many virtues of a maillard reaction inhibitor.
Voziyan PA, Hudson BG (2005) Ann N Y Acad Sci 1043(): 807-16
Citation ⋅ 16037308 (PubMed)70. Identification of S-hydroxylysyl-methionine as the covalent cross-link of the noncollagenous (NC1) hexamer of the alpha1alpha1alpha2 collagen IV network: a role for the post-translational modification of lysine 211 to hydroxylysine 211 in hexamer assembly.
Vanacore RM, Friedman DB, Ham AJ, Sundaramoorthy M, Hudson BG (2005) J Biol Chem 280(32): 29300-10
Citation ⋅ 15951440 (PubMed)71. Goodpasture autoantibodies unmask cryptic epitopes by selectively dissociating autoantigen complexes lacking structural reinforcement: novel mechanisms for immune privilege and autoimmune pathogenesis.
Borza DB, Bondar O, Colon S, Todd P, Sado Y, Neilson EG, Hudson BG (2005) J Biol Chem 280(29): 27147-54
Citation ⋅ 15917228 (PubMed)72. Pyridoxamine as a multifunctional pharmaceutical: targeting pathogenic glycation and oxidative damage.
Voziyan PA, Hudson BG (2005) Cell Mol Life Sci 62(15): 1671-81
Citation ⋅ 15905958 (PubMed)73. Experimental autoimmune Goodpasture's disease: a pathogenetic role for both effector cells and antibody in injury.
Dean EG, Wilson GR, Li M, Edgtton KL, O'Sullivan KM, Hudson BG, Holdsworth SR, Kitching AR (2005) Kidney Int 67(2): 566-75
Citation ⋅ 15673304 (PubMed)74. Pyridoxamine lowers kidney crystals in experimental hyperoxaluria: a potential therapy for primary hyperoxaluria.
Chetyrkin SV, Kim D, Belmont JM, Scheinman JI, Hudson BG, Voziyan PA (2005) Kidney Int 67(1): 53-60
Citation ⋅ 15610227 (PubMed)75. The molecular basis of Goodpasture and Alport syndromes: beacons for the discovery of the collagen IV family.
Hudson BG (2004) J Am Soc Nephrol 15(10): 2514-27
Citation ⋅ 15466256 (PubMed)76. The alpha1.alpha2 network of collagen IV. Reinforced stabilization of the noncollagenous domain-1 by noncovalent forces and the absence of Met-Lys cross-links.
Vanacore RM, Shanmugasundararaj S, Friedman DB, Bondar O, Hudson BG, Sundaramoorthy M (2004) J Biol Chem 279(43): 44723-30
Citation ⋅ 15299013 (PubMed)77. Interaction of Dr adhesin with collagen type IV is a critical step in Escherichia coli renal persistence.
Selvarangan R, Goluszko P, Singhal J, Carnoy C, Moseley S, Hudson B, Nowicki S, Nowicki B (2004) Infect Immun 72(8): 4827-35
Citation ⋅ 15271945 (PubMed) PMC470682 (PubMed Central)78. Experimental autoimmune anti-glomerular basement membrane glomerulonephritis: a protective role for IFN-gamma.
Kitching AR, Turner AL, Semple T, Li M, Edgtton KL, Wilson GR, Timoshanko JR, Hudson BG, Holdsworth SR (2004) J Am Soc Nephrol 15(7): 1764-74
Citation ⋅ 15213264 (PubMed)79. Pathogenesis of Goodpasture syndrome: a molecular perspective.
Borza DB, Neilson EG, Hudson BG (2003) Semin Nephrol 23(6): 522-31
Citation ⋅ 14631560 (PubMed)80. Alpha(v)beta3 and alpha(v)beta5 integrins bind both the proximal RGD site and non-RGD motifs within noncollagenous (NC1) domain of the alpha3 chain of type IV collagen: implication for the mechanism of endothelia cell adhesion.
Pedchenko V, Zent R, Hudson BG (2004) J Biol Chem 279(4): 2772-80
Citation ⋅ 14610079 (PubMed)81. A human-mouse chimera of the alpha3alpha4alpha5(IV) collagen protomer rescues the renal phenotype in Col4a3-/- Alport mice.
Heidet L, Borza DB, Jouin M, Sich M, Mattei MG, Sado Y, Hudson BG, Hastie N, Antignac C, Gubler MC (2003) Am J Pathol 163(4): 1633-44
Citation ⋅ 14507670 (PubMed) PMC1868284 (PubMed Central)82. Unusual susceptibility of heme proteins to damage by glucose during non-enzymatic glycation.
Cussimanio BL, Booth AA, Todd P, Hudson BG, Khalifah RG (2003) Biophys Chem 105(2-3): 743-55
Citation ⋅ 14499930 (PubMed)83. Modification of proteins in vitro by physiological levels of glucose: pyridoxamine inhibits conversion of Amadori intermediate to advanced glycation end-products through binding of redox metal ions.
Voziyan PA, Khalifah RG, Thibaudeau C, Yildiz A, Jacob J, Serianni AS, Hudson BG (2003) J Biol Chem 278(47): 46616-24
Citation ⋅ 12975371 (PubMed)84. Alport's syndrome, Goodpasture's syndrome, and type IV collagen.
Hudson BG, Tryggvason K, Sundaramoorthy M, Neilson EG (2003) N Engl J Med 348(25): 2543-56
Citation ⋅ 12815141 (PubMed)85. Molecular characterization of the target antigens of anti-glomerular basement membrane antibody disease.
Borza DB, Hudson BG (2003) Springer Semin Immunopathol 24(4): 345-61
Citation ⋅ 12778332 (PubMed)86. Crescentic glomerulonephritis and subepidermal blisters with autoantibodies to alpha5 and alpha6 chains of type IV collagen.
Ghohestani RF, Rotunda SL, Hudson B, Gaughan WJ, Farber JL, Webster G, Uitto J (2003) Lab Invest 83(5): 605-11
Citation ⋅ 12746470 (PubMed)87. Quaternary organization of the goodpasture autoantigen, the alpha 3(IV) collagen chain. Sequestration of two cryptic autoepitopes by intrapromoter interactions with the alpha4 and alpha5 NC1 domains.
Borza DB, Bondar O, Todd P, Sundaramoorthy M, Sado Y, Ninomiya Y, Hudson BG (2002) J Biol Chem 277(42): 40075-83
Citation ⋅ 12193605 (PubMed)88. Crystal structure of NC1 domains. Structural basis for type IV collagen assembly in basement membranes.
Sundaramoorthy M, Meiyappan M, Todd P, Hudson BG (2002) J Biol Chem 277(34): 31142-53
Citation ⋅ 11970952 (PubMed)89. Of mice and men: murine models of anti-GBM antibody nephritis.
Borza DB, Hudson BG (2002) Kidney Int 61(5): 1905-6
Citation ⋅ 11967044 (PubMed)90. A post-Amadori inhibitor pyridoxamine also inhibits chemical modification of proteins by scavenging carbonyl intermediates of carbohydrate and lipid degradation.
Voziyan PA, Metz TO, Baynes JW, Hudson BG (2002) J Biol Chem 277(5): 3397-403
Citation ⋅ 11729198 (PubMed)91. The NC1 domain of collagen IV encodes a novel network composed of the alpha 1, alpha 2, alpha 5, and alpha 6 chains in smooth muscle basement membranes.
Borza DB, Bondar O, Ninomiya Y, Sado Y, Naito I, Todd P, Hudson BG (2001) J Biol Chem 276(30): 28532-40
Citation ⋅ 11375996 (PubMed)92. Hydrophobic amino acid residues are critical for the immunodominant epitope of the Goodpasture autoantigen. A molecular basis for the cryptic nature of the epitope.
David M, Borza DB, Leinonen A, Belmont JM, Hudson BG (2001) J Biol Chem 276(9): 6370-7
Citation ⋅ 11098057 (PubMed)93. Type IV collagen of the glomerular basement membrane. Evidence that the chain specificity of network assembly is encoded by the noncollagenous NC1 domains.
Boutaud A, Borza DB, Bondar O, Gunwar S, Netzer KO, Singh N, Ninomiya Y, Sado Y, Noelken ME, Hudson BG (2000) J Biol Chem 275(39): 30716-24
Citation ⋅ 10896941 (PubMed)94. The alpha 5 chain of type IV collagen is the target of IgG autoantibodies in a novel autoimmune disease with subepidermal blisters and renal insufficiency.
Ghohestani RF, Hudson BG, Claudy A, Uitto J (2000) J Biol Chem 275(21): 16002-6
Citation ⋅ 10821854 (PubMed)95. New functions for non-collagenous domains of human collagen type IV. Novel integrin ligands inhibiting angiogenesis and tumor growth in vivo.
Petitclerc E, Boutaud A, Prestayko A, Xu J, Sado Y, Ninomiya Y, Sarras MP, Hudson BG, Brooks PC (2000) J Biol Chem 275(11): 8051-61
Citation ⋅ 10713126 (PubMed)96. The goodpasture autoantigen. Identification of multiple cryptic epitopes on the NC1 domain of the alpha3(IV) collagen chain.
Borza DB, Netzer KO, Leinonen A, Todd P, Cervera J, Saus J, Hudson BG (2000) J Biol Chem 275(8): 6030-7
Citation ⋅ 10681598 (PubMed)97. Recurrent Goodpasture's disease due to a monoclonal IgA-kappa circulating antibody.
Fervenza FC, Terreros D, Boutaud A, Hudson BG, Williams RA, Donadio JV, Schwab TR (1999) Am J Kidney Dis 34(3): 549-55
Citation ⋅ 10469867 (PubMed)98. Amadorins: novel post-Amadori inhibitors of advanced glycation reactions.
Khalifah RG, Baynes JW, Hudson BG (1999) Biochem Biophys Res Commun 257(2): 251-8
Citation ⋅ 10198198 (PubMed)99. The goodpasture autoantigen. Mapping the major conformational epitope(s) of alpha3(IV) collagen to residues 17-31 and 127-141 of the NC1 domain.
Netzer KO, Leinonen A, Boutaud A, Borza DB, Todd P, Gunwar S, Langeveld JP, Hudson BG (1999) J Biol Chem 274(16): 11267-74
Citation ⋅ 10196215 (PubMed)100. Goodpasture antigen: expression of the full-length alpha3(IV) chain of collagen IV and localization of epitopes exclusively to the noncollagenous domain.
Leinonen A, Netzer KO, Boutaud A, Gunwar S, Hudson BG (1999) Kidney Int 55(3): 926-35
Citation ⋅ 10027929 (PubMed)101. Role of distinct type IV collagen networks in glomerular development and function.
Harvey SJ, Zheng K, Sado Y, Naito I, Ninomiya Y, Jacobs RM, Hudson BG, Thorner PS (1998) Kidney Int 54(6): 1857-66
Citation ⋅ 9853250 (PubMed)102. Experimental Goodpasture's syndrome in Wistar-Kyoto rats immunized with alpha3 chain of type IV collagen.
Abbate M, Kalluri R, Corna D, Yamaguchi N, McCluskey RT, Hudson BG, Andres G, Zoja C, Remuzzi G (1998) Kidney Int 54(5): 1550-61
Citation ⋅ 9844131 (PubMed)103. Seventy-year-old man with pulmonary problems and renal failure: a clinicopathologic correlation conference from the University of Oklahoma College of Medicine.
Kinasewitz G, Fine D, Good TD, Eaton B, Silva F, Hudson B (1997) J Okla State Med Assoc 90(8): 431-41
Citation ⋅ 9816389 (PubMed)104. Comparative analysis of the noncollagenous NC1 domain of type IV collagen: identification of structural features important for assembly, function, and pathogenesis.
Netzer KO, Suzuki K, Itoh Y, Hudson BG, Khalifah RG (1998) Protein Sci 7(6): 1340-51
Citation ⋅ 9655338 (PubMed) PMC2144033 (PubMed Central)105. Identification and localization of type IV collagen chains in the inner ear cochlea.
Kalluri R, Gattone VH, Hudson BG (1998) Connect Tissue Res 37(1-2): 143-50
Citation ⋅ 9643653 (PubMed)106. Glomerular basement membrane. Identification of a novel disulfide-cross-linked network of alpha3, alpha4, and alpha5 chains of type IV collagen and its implications for the pathogenesis of Alport syndrome.
Gunwar S, Ballester F, Noelken ME, Sado Y, Ninomiya Y, Hudson BG (1998) J Biol Chem 273(15): 8767-75
Citation ⋅ 9535854 (PubMed)107. Induction of anti-GBM nephritis in rats by recombinant alpha 3(IV)NC1 and alpha 4(IV)NC1 of type IV collagen.
Sado Y, Boutaud A, Kagawa M, Naito I, Ninomiya Y, Hudson BG (1998) Kidney Int 53(3): 664-71
Citation ⋅ 9507212 (PubMed)108. Nonenzymatic glycation of type IV collagen and matrix metalloproteinase susceptibility.
Mott JD, Khalifah RG, Nagase H, Shield CF, Hudson JK, Hudson BG (1997) Kidney Int 52(5): 1302-12
Citation ⋅ 9350653 (PubMed)109. Seminiferous tubule basement membrane. Composition and organization of type IV collagen chains, and the linkage of alpha3(IV) and alpha5(IV) chains.
Kahsai TZ, Enders GC, Gunwar S, Brunmark C, Wieslander J, Kalluri R, Zhou J, Noelken ME, Hudson BG (1997) J Biol Chem 272(27): 17023-32
Citation ⋅ 9202017 (PubMed)110. Isoform switching of type IV collagen is developmentally arrested in X-linked Alport syndrome leading to increased susceptibility of renal basement membranes to endoproteolysis.
Kalluri R, Shield CF, Todd P, Hudson BG, Neilson EG (1997) J Clin Invest 99(10): 2470-8
Citation ⋅ 9153291 (PubMed) PMC508088 (PubMed Central)111. In vitro kinetic studies of formation of antigenic advanced glycation end products (AGEs). Novel inhibition of post-Amadori glycation pathways.
Booth AA, Khalifah RG, Todd P, Hudson BG (1997) J Biol Chem 272(9): 5430-7
Citation ⋅ 9038143 (PubMed)112. Goodpasture syndrome: selective removal of anti-alpha 3 (IV) collagen autoantibodies. A potential therapeutic alternative to plasmapheresis.
Boutaud AA, Kalluri R, Kahsai TZ, Noelken ME, Hudson BG (1996) Exp Nephrol 4(4): 205-12
Citation ⋅ 8864724 (PubMed)113. Identification of the endothelial cell binding site for factor IX.
Cheung WF, van den Born J, Kühn K, Kjellén L, Hudson BG, Stafford DW (1996) Proc Natl Acad Sci U S A 93(20): 11068-73
Citation ⋅ 8855310 (PubMed) PMC38285 (PubMed Central)114. Autoreactive T-cells in Goodpasture's syndrome recognize the N-terminal NC1 domain on alpha 3 type IV collagen.
Merkel F, Kalluri R, Marx M, Enders U, Stevanovic S, Giegerich G, Neilson EG, Rammensee HG, Hudson BG, Weber M (1996) Kidney Int 49(4): 1127-33
Citation ⋅ 8691734 (PubMed)115. Kinetics of nonenzymatic glycation of ribonuclease A leading to advanced glycation end products. Paradoxical inhibition by ribose leads to facile isolation of protein intermediate for rapid post-Amadori studies.
Khalifah RG, Todd P, Booth AA, Yang SX, Mott JD, Hudson BG (1996) Biochemistry 35(15): 4645-54
Citation ⋅ 8664253 (PubMed)116. Coordinate gene expression of the alpha3, alpha4, and alpha5 chains of collagen type IV. Evidence from a canine model of X-linked nephritis with a COL4A5 gene mutation.
Thorner PS, Zheng K, Kalluri R, Jacobs R, Hudson BG (1996) J Biol Chem 271(23): 13821-8
Citation ⋅ 8662866 (PubMed)117. The Goodpasture autoantigen. Structural delineation of two immunologically privileged epitopes on alpha3(IV) chain of type IV collagen.
Kalluri R, Sun MJ, Hudson BG, Neilson EG (1996) J Biol Chem 271(15): 9062-8
Citation ⋅ 8621555 (PubMed)118. Thiamine pyrophosphate and pyridoxamine inhibit the formation of antigenic advanced glycation end-products: comparison with aminoguanidine.
Booth AA, Khalifah RG, Hudson BG (1996) Biochem Biophys Res Commun 220(1): 113-9
Citation ⋅ 8602828 (PubMed)119. Identification of the alpha 3 chain of type IV collagen as the common autoantigen in antibasement membrane disease and Goodpasture syndrome.
Kalluri R, Wilson CB, Weber M, Gunwar S, Chonko AM, Neilson EG, Hudson BG (1995) J Am Soc Nephrol 6(4): 1178-85
Citation ⋅ 8589284 (PubMed)120. Developmental changes in seminiferous tubule extracellular matrix components of the mouse testis: alpha 3(IV) collagen chain expressed at the initiation of spermatogenesis.
Enders GC, Kahsai TZ, Lian G, Funabiki K, Killen PD, Hudson BG (1995) Biol Reprod 53(6): 1489-99
Citation ⋅ 8562707 (PubMed)121. Specificity of Goodpasture autoantibodies for the recombinant noncollagenous domains of human type IV collagen.
Neilson EG, Kalluri R, Sun MJ, Gunwar S, Danoff T, Mariyama M, Myers JC, Reeders ST, Hudson BG (1993) J Biol Chem 268(12): 8402-5
Citation ⋅ 8473281 (PubMed)122. Reductive cleavage of the disulfide bonds of the collagen IV noncollagenous domain in aqueous sodium dodecyl sulfate: absence of intermolecular nondisulfide cross-links.
Reddy GK, Hudson BG, Bailey AJ, Noelken ME (1993) Biochem Biophys Res Commun 190(1): 277-82
Citation ⋅ 8422253 (PubMed)123. Characterization and quantitation of the circulating forms of serum transferrin receptor using domain-specific antibodies.
Shih YJ, Baynes RD, Hudson BG, Cook JD (1993) Blood 81(1): 234-8
Citation ⋅ 8417792 (PubMed)124. Production of the serum form of the transferrin receptor by a cell membrane-associated serine protease.
Baynes RD, Shih YJ, Hudson BG, Cook JD (1993) Proc Soc Exp Biol Med 204(1): 65-9
Citation ⋅ 8372098 (PubMed)125. Structure and composition of type IV collagen of bovine aorta.
Reddy GK, Gunwar S, Kalluri R, Hudson BG, Noelken ME (1993) Biochim Biophys Acta 1157(3): 241-51
Citation ⋅ 8323954 (PubMed)126. Type IV collagen: structure, gene organization, and role in human diseases. Molecular basis of Goodpasture and Alport syndromes and diffuse leiomyomatosis.
Hudson BG, Reeders ST, Tryggvason K (1993) J Biol Chem 268(35): 26033-6
Citation ⋅ 8253711 (PubMed)127. COL4A5 gene deletion and production of post-transplant anti-alpha 3(IV) collagen alloantibodies in Alport syndrome.
Kalluri R, Weber M, Netzer KO, Sun MJ, Neilson EG, Hudson BG (1994) Kidney Int 45(3): 721-6
Citation ⋅ 8196274 (PubMed)128. Identification of the membrane remnants of transferrin receptor with domain-specific antibodies.
Baynes RD, Shih YJ, Hudson BG, Cook JD (1994) J Lab Clin Med 123(3): 407-14
Citation ⋅ 8133153 (PubMed)129. Hydra cell aggregate development is blocked by selective fragments of fibronectin and type IV collagen.
Zhang X, Hudson BG, Sarras MP (1994) Dev Biol 164(1): 10-23
Citation ⋅ 8026615 (PubMed)130. The alpha 3 chain of type IV collagen induces autoimmune Goodpasture syndrome.
Kalluri R, Gattone VH, Noelken ME, Hudson BG (1994) Proc Natl Acad Sci U S A 91(13): 6201-5
Citation ⋅ 8016138 (PubMed) PMC44166 (PubMed Central)131. The chain composition of aorta basement membrane collagen IV, localization of the chains in aorta and supramolecular assembly of the collagen IV protomers.
Noelken ME, Reddy GK, Kalluri R, Gunwar S, Hudson BG (1994) Contrib Nephrol 107(): 216-9
Citation ⋅ 8004971 (PubMed)132. Structure and organization of type IV collagen of renal glomerular basement membrane.
Hudson BG, Kalluri R, Gunwar S, Noelken ME (1994) Contrib Nephrol 107(): 163-7
Citation ⋅ 8004963 (PubMed)133. Pathology of glomerular basement membrane nephropathy.
Hudson BG, Kalluri R, Tryggvason K (1994) Curr Opin Nephrol Hypertens 3(3): 334-9
Citation ⋅ 7922261 (PubMed)134. A COL4A3 gene mutation and post-transplant anti-alpha 3(IV) collagen alloantibodies in Alport syndrome.
Kalluri R, van den Heuvel LP, Smeets HJ, Schroder CH, Lemmink HH, Boutaud A, Neilson EG, Hudson BG (1995) Kidney Int 47(4): 1199-204
Citation ⋅ 7783419 (PubMed)135. Molecular characteristics of the Goodpasture autoantigen.
Hudson BG, Kalluri R, Gunwar S, Noelken ME, Mariyama M, Reeders ST (1993) Kidney Int 43(1): 135-9
Citation ⋅ 7679455 (PubMed)136. Comparative distribution of the alpha 1(IV), alpha 5(IV), and alpha 6(IV) collagen chains in normal human adult and fetal tissues and in kidneys from X-linked Alport syndrome patients.
Peissel B, Geng L, Kalluri R, Kashtan C, Rennke HG, Gallo GR, Yoshioka K, Sun MJ, Hudson BG, Neilson EG (1995) J Clin Invest 96(4): 1948-57
Citation ⋅ 7560087 (PubMed) PMC185832 (PubMed Central)137. Changes in chemical composition of anterior lens capsules of cataractous human eyes as a function of age.
Peczon BD, Peczon JD, Cintron C, Hudson BG (1980) Exp Eye Res 30(2): 155-65
Citation ⋅ 7418737 (PubMed)138. The structure of the asparagine-linked carbohydrate unit of rat alpha-lactalbumin.
Prasad R, Hudson BG, Strickland DK, Ebner KE (1980) J Biol Chem 255(4): 1248-51
Citation ⋅ 7354024 (PubMed)139. Comparison of the chemical and polypeptide composition of tubular and glomerular basement membranes.
Butkowski RJ, Grantham JJ, Hudson BG (1980) Ren Physiol 3(1-6): 14-22
Citation ⋅ 7323408 (PubMed)140. Detergent-prepared glomerular basement membrane is composed of a heterogeneous group of polypeptides.
Fox JW, Butkowski RJ, Hudson BG (1981) J Biol Chem 256(17): 9313-5
Citation ⋅ 7263717 (PubMed)141. Characterization of the collagenous domain of tubular basement membrane.
Butkowski RJ, Brungardt GS, Grantham JJ, Hudson BG (1981) J Biol Chem 256(14): 7603-9
Citation ⋅ 7251611 (PubMed)142. Bovine glomerular basement membrane. Characterization of an alpha-size collagenous polypeptide.
Dean DC, Peczon BD, Noelken ME, Hudson BG (1981) J Biol Chem 256(14): 7543-8
Citation ⋅ 7251609 (PubMed)143. Estimation of the size of collagenous polypeptides by sodium dodecyl sulfate--polyacrylamide gel electrophoresis.
Noelken ME, Wisdom BJ, Hudson BG (1981) Anal Biochem 110(1): 131-6
Citation ⋅ 7212256 (PubMed)144. Characterization of the collagenous domain of bovine glomerular basement membrane.
Hudson BG, Fox JW (1980) Ren Physiol 3(1-6): 9-13
Citation ⋅ 6798651 (PubMed)145. Intestinal basement membrane of Ascaris suum. Physical properties of the collagenous domain.
Hung CH, Noelken ME, Hudson BG (1981) J Biol Chem 256(8): 3822-6
Citation ⋅ 6783646 (PubMed)146. Bovine glomerular basement membrane. Properties of the collagenous domain.
West TW, Fox JW, Jodlowski M, Freytag JW, Hudson BG (1980) J Biol Chem 255(21): 10451-9
Citation ⋅ 6776117 (PubMed)147. Intestinal basement membrane of Ascaris suum. Properties of the collagenous domain.
Hung CH, Butkowski RJ, Hudson BG (1980) J Biol Chem 255(10): 4964-71
Citation ⋅ 6768727 (PubMed)148. Goodpasture antigen of the glomerular basement membrane: localization to noncollagenous regions of type IV collagen.
Wieslander J, Barr JF, Butkowski RJ, Edwards SJ, Bygren P, Heinegård D, Hudson BG (1984) Proc Natl Acad Sci U S A 81(12): 3838-42
Citation ⋅ 6328527 (PubMed) PMC345316 (PubMed Central)149. Isolation of type IV procollagen-like polypeptides from glomerular basement membrane. Characterization of pro-alpha 1(IV).
Dean DC, Barr JF, Freytag JW, Hudson BG (1983) J Biol Chem 258(1): 590-6
Citation ⋅ 6294114 (PubMed)150. Fractionation of protein solutions by membrane partition chromatography.
Blatt WF, Hudson BG, Robinson SM, Zipilivan EM (1967) Nature 216(5114): 511-3
Citation ⋅ 6057272 (PubMed)151. Removal of low molecular weight contaminants from 131-I-labeled insulin by selective ultrafiltration.
Blatt WF, Hudson BG (1968) Anal Biochem 26(2): 329-33
Citation ⋅ 5758048 (PubMed)152. A modified ultrafiltration cell for separating the products of proteolysis.
Blatt WF, Hudson BG, Robinson SM, Zipilivan EM (1968) Anal Biochem 22(1): 161-5
Citation ⋅ 5636947 (PubMed)153. Fractionation of glycoprotein components of the reduced alkylated renal glomerular basement membrane.
Hudson BG, Spiro RG (1972) J Biol Chem 247(13): 4239-47
Citation ⋅ 5064342 (PubMed)154. Studies on the native and reduced alkylated renal glomerular basement membrane. Solubility, subunit size, and reaction with cyanogen bromide.
Hudson BG, Spiro RG (1972) J Biol Chem 247(13): 4229-38
Citation ⋅ 5035690 (PubMed)155. Separation of immunologically active fragments by membrane partition chromatography.
Zipilivan EM, Hudson BG, Blatt WF (1969) Anal Biochem 30(1): 91-8
Citation ⋅ 4978648 (PubMed)156. An accelerated single column procedure for the programmed analysis of naturally-occuring amino acids of collagen and basement membrane.
Guire P, Riquetti P, Hudson BG (1974) J Chromatogr 90(2): 350-3
Citation ⋅ 4833161 (PubMed)157. A rapid automatic analysis of hydroxylysine, hydroxylysine glycosides, and methionine sulfoxide in collagen and basement membrane.
Odell V, Wegener L, Peczon B, Hudson BG (1974) J Chromatogr 88(2): 245-52
Citation ⋅ 4814348 (PubMed)158. Chemical and physical properties of serum transferrins from several species.
Hudson BG, Ono M, Brockway WJ, Castellino FJ (1973) Biochemistry 12(6): 1047-53
Citation ⋅ 4734658 (PubMed)159. Micro-chromatographic and radiochemical analysis of glycopeptides.
Lehman ED, Hudson BG, Ebner KE (1973) J Chromatogr 76(2): 345-50
Citation ⋅ 4689608 (PubMed)160. Enzymic synthesis of lactose- 14 C (galactosyl- 14 C) and lactose- 3 H (glucosyl- 3 H).
Hudson BG, McKenzie L, Ebner KE (1972) Anal Biochem 48(2): 524-8
Citation ⋅ 4672221 (PubMed)161. The overoxidation of carbohydrates with sodium metaperiodate.
Hudson BG, Barker R (1967) J Org Chem 32(7): 2101-9
Citation ⋅ 4292590 (PubMed)162. Tubular basement membrane changes in 2-amino-4,5-diphenylthiazole-induced polycystic disease.
Butkowski RJ, Carone FA, Grantham JJ, Hudson BG (1985) Kidney Int 28(5): 744-51
Citation ⋅ 4087690 (PubMed)163. Intestinal basement membrane of Ascaris suum. Molecular organization and properties of the collagen molecules.
Noelken ME, Wisdom BJ, Dean DC, Hung CH, Hudson BG (1986) J Biol Chem 261(10): 4706-14
Citation ⋅ 3957913 (PubMed)164. Characterization of the human Goodpasture antigen.
Wieslander J, Kataja M, Hudson BG (1987) Clin Exp Immunol 69(2): 332-40
Citation ⋅ 3652534 (PubMed) PMC1542417 (PubMed Central)165. Identification of the Goodpasture antigen as the alpha 3(IV) chain of collagen IV.
Saus J, Wieslander J, Langeveld JP, Quinones S, Hudson BG (1988) J Biol Chem 263(26): 13374-80
Citation ⋅ 3417661 (PubMed)166. Structural heterogeneity of the noncollagenous domain of basement membrane collagen.
Langeveld JP, Wieslander J, Timoneda J, McKinney P, Butkowski RJ, Wisdom BJ, Hudson BG (1988) J Biol Chem 263(21): 10481-8
Citation ⋅ 3392020 (PubMed)167. Degradation of basement membranes by human matrix metalloproteinase 3 (stromelysin).
Bejarano PA, Noelken ME, Suzuki K, Hudson BG, Nagase H (1988) Biochem J 256(2): 413-9
Citation ⋅ 3223920 (PubMed) PMC1135425 (PubMed Central)168. Properties of the globular domain of type IV collagen and its relationship to the Goodpasture antigen.
Butkowski RJ, Wieslander J, Wisdom BJ, Barr JF, Noelken ME, Hudson BG (1985) J Biol Chem 260(6): 3739-47
Citation ⋅ 2982876 (PubMed)169. Goodpasture syndrome: molecular architecture and function of basement membrane antigen.
Hudson BG, Wieslander J, Wisdom BJ, Noelken ME (1989) Lab Invest 61(3): 256-69
Citation ⋅ 2671489 (PubMed)170. Degradation of basement membranes by Pseudomonas aeruginosa elastase.
Bejarano PA, Langeveld JP, Hudson BG, Noelken ME (1989) Infect Immun 57(12): 3783-7
Citation ⋅ 2509368 (PubMed) PMC259905 (PubMed Central)171. Localization of the Goodpasture epitope to a novel chain of basement membrane collagen.
Butkowski RJ, Langeveld JP, Wieslander J, Hamilton J, Hudson BG (1987) J Biol Chem 262(16): 7874-7
Citation ⋅ 2438283 (PubMed)172. Physical and immunochemical studies of the globular domain of type IV collagen. Cryptic properties of the Goodpasture antigen.
Wieslander J, Langeveld J, Butkowski R, Jodlowski M, Noelken M, Hudson BG (1985) J Biol Chem 260(14): 8564-70
Citation ⋅ 2409091 (PubMed)173. Unusual dissociative behavior of the noncollagenous domain (hexamer) of basement membrane collagen during electrophoresis and chromatofocusing.
Timoneda J, Gunwar S, Monfort G, Saus J, Noelken ME, Hudson BG (1990) Connect Tissue Res 24(3-4): 169-86
Citation ⋅ 2376121 (PubMed)174. Glomerular basement membrane: evidence for collagenous domain of the alpha 3 and alpha 4 chains of collagen IV.
Fagg WR, Timoneda J, Schwartz CE, Langeveld JP, Noelken ME, Hudson BG (1990) Biochem Biophys Res Commun 170(1): 322-7
Citation ⋅ 2372295 (PubMed)175. Glomerular basement membrane. Identification of a fourth chain, alpha 4, of type IV collagen.
Gunwar S, Saus J, Noelken ME, Hudson BG (1990) J Biol Chem 265(10): 5466-9
Citation ⋅ 2318822 (PubMed)176. Serum transferrin receptor is a truncated form of tissue receptor.
Shih YJ, Baynes RD, Hudson BG, Flowers CH, Skikne BS, Cook JD (1990) J Biol Chem 265(31): 19077-81
Citation ⋅ 2229063 (PubMed)177. A non-mammalian in vivo model for cellular and molecular analysis of glucose-mediated thickening of basement membranes.
Zhang X, Huff JK, Hudson BG, Sarras MP (1990) Diabetologia 33(11): 704-7
Citation ⋅ 2076802 (PubMed)178. Bovine glomerular basement membrane. Location and structure of the asparagine-linked oligosaccharide units and their potential role in the assembly of the 7 S collagen IV tetramer.
Langeveld JP, Noelken ME, Hård K, Todd P, Vliegenthart JF, Rouse J, Hudson BG (1991) J Biol Chem 266(4): 2622-31
Citation ⋅ 1990011 (PubMed)179. Alveolar basement membrane: molecular properties of the noncollagenous domain (hexamer) of collagen IV and its reactivity with Goodpasture autoantibodies.
Gunwar S, Bejarano PA, Kalluri R, Langeveld JP, Wisdom BJ, Noelken ME, Hudson BG (1991) Am J Respir Cell Mol Biol 5(2): 107-12
Citation ⋅ 1892641 (PubMed)180. Characterization of transferrin receptor released by K562 erythroleukemia cells.
Baynes RD, Shih YJ, Hudson BG, Cook JD (1991) Proc Soc Exp Biol Med 197(4): 416-23
Citation ⋅ 1871153 (PubMed)181. Glomerular basement membrane. Identification of dimeric subunits of the noncollagenous domain (hexamer) of collagen IV and the Goodpasture antigen.
Gunwar S, Ballester F, Kalluri R, Timoneda J, Chonko AM, Edwards SJ, Noelken ME, Hudson BG (1991) J Biol Chem 266(23): 15318-24
Citation ⋅ 1869555 (PubMed)182. Properties of the collagenous domain of the alpha 3(IV) chain, the Goodpasture antigen, of lens basement membrane collagen. Selective cleavage of alpha (IV) chains with retention of their triple helical structure and noncollagenous domain.
Gunwar S, Noelken ME, Hudson BG (1991) J Biol Chem 266(21): 14088-94
Citation ⋅ 1856232 (PubMed)183. Extracellular matrix (mesoglea) of Hydra vulgaris. I. Isolation and characterization.
Sarras MP, Madden ME, Zhang XM, Gunwar S, Huff JK, Hudson BG (1991) Dev Biol 148(2): 481-94
Citation ⋅ 1743396 (PubMed)184. Goodpasture syndrome. Localization of the epitope for the autoantibodies to the carboxyl-terminal region of the alpha 3(IV) chain of basement membrane collagen.
Kalluri R, Gunwar S, Reeders ST, Morrison KC, Mariyama M, Ebner KE, Noelken ME, Hudson BG (1991) J Biol Chem 266(35): 24018-24
Citation ⋅ 1721062 (PubMed)185. The pathogenesis of Alport syndrome involves type IV collagen molecules containing the alpha 3(IV) chain: evidence from anti-GBM nephritis after renal transplantation.
Hudson BG, Kalluri R, Gunwar S, Weber M, Ballester F, Hudson JK, Noelken ME, Sarras M, Richardson WR, Saus J (1992) Kidney Int 42(1): 179-87
Citation ⋅ 1635348 (PubMed)186. Type IV collagen of Engelbreth-Holm-Swarm tumor matrix: identification of constituent chains.
Wisdom BJ, Gunwar S, Hudson MD, Noelken ME, Hudson BG (1992) Connect Tissue Res 27(4): 225-34
Citation ⋅ 1576823 (PubMed)187. The alpha 4(IV) chain of basement membrane collagen. Isolation of cDNAs encoding bovine alpha 4(IV) and comparison with other type IV collagens.
Mariyama M, Kalluri R, Hudson BG, Reeders ST (1992) J Biol Chem 267(2): 1253-8
Citation ⋅ 1370461 (PubMed)188. Rapidly Progressive Renal Failure in a Young Woman.
Scarpelli DG (1975) N Engl J Med 293(18): 922-7
Citation ⋅ 1177991 (PubMed)189. Bovine renal glomerular basement membrane. Isolation and characterization of a glycoprotein component.
Oho M, Riquetti P, Hudson BG (1975) J Biol Chem 250(19): 7780-7
Citation ⋅ 1176447 (PubMed)190. Chemical studies of erythrocyte membrane glycoproteins from several species.
Hudson BG, Wegener LJ, Wingate JM, Carraway KL (1975) Comp Biochem Physiol B 51(1): 127-35
Citation ⋅ 1139875 (PubMed)191. Distribution of prothrombin carbohydrate units upon thrombin activation.
Hudson BG, Heldebrant CM, Mann KG (1975) Thromb Res 6(3): 215-21
Citation ⋅ 1114489 (PubMed)192. Bovine renal glomerular basement membrane. Assessment of proteolysis during isolation.
Freytag JW, Ohno M, Hudson BG (1976) Biochem Biophys Res Commun 72(3): 796-802
Citation ⋅ 985518 (PubMed)193. Alterations of red cell membranes from phenylhydrazine-treated rabbits.
Tsao D, Colton DG, Chang JS, Buck RL, Hudson BG, Carraway KL (1977) Biochim Biophys Acta 469(1): 61-73
Citation ⋅ 889825 (PubMed)194. Estimation of molecular weights of peptides and glycopeptides by thin-layer gel filtration.
Hung CH, Strickland DK, Hudson BG (1977) Anal Biochem 80(1): 91-100
Citation ⋅ 883648 (PubMed)195. Intestinal basement membrane of Ascaris suum. Characterization of carbohydrate units.
Peczon BD, Wegener LJ, Hung CH, Hudson BG (1977) J Biol Chem 252(11): 4002-6
Citation ⋅ 863912 (PubMed)196. Intestinal basement membrane of Ascaris suum. Analysis of polypeptide components.
Hung CH, Ohno M, Freytag JW, Hudson BG (1977) J Biol Chem 252(11): 3995-4001
Citation ⋅ 863911 (PubMed)197. Isolation and characterization of rat alpha-lactalbumin: a glycoprotein.
Brown RC, Fish WW, Hudson BG, Ebner KE (1977) Biochim Biophys Acta 491(1): 82-92
Citation ⋅ 849470 (PubMed)198. Studies on the carbohydrate structure of bovine milk galactosyltransferase.
Lehman ED, Hudson BG, Ebner KE (1975) FEBS Lett 54(1): 65-9
Citation ⋅ 805714 (PubMed)199. Glomerular basement membrane. Studies on its structure and interaction with platelets.
Freytag JW, Dalrymple PN, Maguire MH, Strickland DK, Carraway KL, Hudson BG (1978) J Biol Chem 253(24): 9069-74
Citation ⋅ 721830 (PubMed)200. Structural studies on rabbit transferrin: isolation and characterization of the glycopeptides.
Strickland DK, Hudson BG (1978) Biochemistry 17(16): 3411-8
Citation ⋅ 687592 (PubMed)201. Large scale preparation of bovine renal glomerular basement membrane in the presence of protease inhibitors.
Freytag JW, Ohno M, Hudson BG (1978) Prep Biochem 8(2-3): 215-24
Citation ⋅ 568787 (PubMed)202. Interaction of bovine platelets with bovine glomerular basement membrane.
Davis JL, Chandler DK, Riquetti P, Rogers S, Kocan KM, Ownby CL, Hudson BG, Carraway KL (1979) Thromb Haemost 42(4): 1217-29
Citation ⋅ 542930 (PubMed)203. Resolution of the charge forms and amino acid sequence and location of a tryptic glycopeptide in rat alpha-lactalbumin.
Prasad R, Hudson BG, Butkowski R, Hamilton JW, Ebner KE (1979) J Biol Chem 254(21): 10607-14
Citation ⋅ 500599 (PubMed)204. Physical properties of collagen--sodium dodecyl sulfate complexes.
Freytag JW, Noelken ME, Hudson BG (1979) Biochemistry 18(21): 4761-8
Citation ⋅ 497168 (PubMed)205. Rabbit tubular basement membrane. Isolation and analysis of polypeptides.
Butkowski RJ, Todd P, Grantham JJ, Hudson BG (1979) J Biol Chem 254(20): 10503-13
Citation ⋅ 489609 (PubMed)206. Structure of the tryptic glycopeptide isolated from rabbit transferrin.
Strickland DK, Hamilton JW, Hudson BG (1979) Biochemistry 18(12): 2549-54
Citation ⋅ 444474 (PubMed)207. Congenital abnormalities induced by heterologous antisera directed against rat kidney glycoproteins isolated by concanavalin A affinity chromatography.
Leung CC, Hung CH, Hudson BG, Brent RL, Cotton RC (1979) Pediatr Res 13(11): 1211-6
Citation ⋅ 316126 (PubMed)208. Membrane glycoprotein differences between normal lactating mammary tissue and the R3230 AC mammary tumor.
Shin BC, Ebner KE, Hudson BG, Carraway KL (1975) Cancer Res 35(5): 1135-40
Citation ⋅ 123479 (PubMed)