Eicosanoid Biology

BASIC science

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                                      Eicosanoid Biology

Eicosanoids comprise a family of biologically active, oxygenated arachidonic acid (AA) metabolites.  Eicosanoids can derive from AA metabolism by the cyclooxygenase, the lipoxygenase, and the Cytochrome P450 monooxygenase pathways. VCKD researchers are actively studying each of these  pathways in renal physiology and pathophysiology in both animal models and in patients.




The Breyer lab is studying the role of prostaglandins in renal physiology and hypertension.  We are interested in the synergism between other pressor hormones and prostaglandins in determining the pressor or depressor effect of prostaglandins.

The Brown lab is studying the effect of genetic polymorphisms that alter the activity of the arachidonic acid ω-hydroxylase CYP4A11 and the epoxyeicoasatrienoic acid-metabolizing enzyme soluble epoxide hydrolase on renal sodium handling and insulin sensitivity, respectively, in humans.

The Harris lab  has had a long term interest in the role of eicosanoid in kidney physiology and pathophysiology. We are currently investigating mechanisms of blood pressure control by COX-2 mediated prostanoids and the role of EETs in regulation of renal epithelial function.

The Luther lab investigates the metabolic links between hypertension, insulin resistance, and diabetes.  The lab uses translational studies in mice and in humans to test how the renin-angiotensin-aldosterone and CYP450 monooxygenase systems impair insulin action, insulin secretion, and vascular function.  In addition, the lab is developing novel non-invasive biomarkers in humans to assess renal epithelial function.

The Pozzi lab studies the role of eicosanoids in diabetic nephropathy and pathological angiogenesis.  We focus our research on the interplay between the products of the arachidonic acid P450 monooxygenases (i.e., EETs and HETEs) and hypertension as well as EETs and nuclear transcription factors in the initiation and progression to diabetic nephropathy and pathological angiogenesis.

The Zhang lab is studying the role of eicosanoids in renal physiology and pathophysiology. We have been focusing on examining the interactions between intrarenal hormones (such as dopamine and angiotensin II and aldosterone) and the AA metabolism pathways (cyclooxygenase, lipoxygenase, and Cytochrome P450 pathways) and their potential roles in renal physiology and pathophysiology.