VCKD Members


Matt Luther MD

Department: Medicine


I am a physician scientist with clinical training in internal medicine, nephrology and hypertension.  I am clinically active in the Vanderbilt Hypertension clinic, which focuses on evaluation and treatment of resistant and secondary forms of hypertension.

The goal of my translational research program is to discover mechanisms of hypertension and complications, through studies in animals and humans. My specialized research expertise includes clinical study design related to metabolism (insulin resistance and secretion) and hypertension.

Research in the Luther lab is multidisciplinary crossing the fields of pharmacology, endocrinology, nephrology, and biochemistry.  We have developed collaborations with investigators with a common interest in translational research to apply state-of-the-art technology to advance our clinical studies.

We have demonstrated that aldosterone, a hormone which regulates blood pressure, produces inflammation and impairs insulin secretion in humans. Using a proteomic approach, we have has also identified novel biomarkers of kidney sodium channel activation in humans.  Additionally, we have demonstrated that the arachidonic acid CYP450 metabolite epoxyeicosatrienoic acid is associated with insulin sensitivity in mice and in humans.   

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